Editorial: Targeted Subcellular Delivery of Anti-cancer Agents

Targeted Cancer Diagnostic and Therapeutic Agents: Delivery by Carriers or Conjugation

Receptors and proteins are overexpressed in many human cancer cell membranes rather than normal tissues and are considered as the main molecular targets. Specific tumor- targeting molecules which have high affinity for these receptors can be valuable tools as carrier molecules for targeted cancer therapy and imaging. Pharmacokinetics and bioavailability of diagnostic and therapeutic agents are ...

Folate receptor-targeted anti-cancer agent delivery

Guest Editorial Molecularly-Targeted and Biological Anti-Cancer Therapy

The advent of the new millennium was characterized by emergence of dozens of so-called new anti-tumour drugs that differed in many substantial aspects from the established, so far widely used chemotherapy agents. Along with the entrance of these novel anti-tumour agents into clinical practice several new terms and designations came up as well, including molecular targeted therapy, biological th...

Aptamer-based Targeted Delivery of miRNA let-7d to Gastric Cancer Cells as a Novel Anti-Tumor Therapeutic Agent

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...

Aptamer-based Targeted Delivery of miRNA let-7d to Gastric Cancer Cells as a Novel Anti-Tumor Therapeutic Agent

miRNAs as one of the potential therapeutic agents have been recently considered for cancer treatment. AS1411 (aptNCL) is a DNA aptamer specifically binding to nucleolin protein on the cancer cell surface with antiproliferative effect. The aim of the study was to develop a conjugate consisted of aptNCL (as targeted delivery of therapeutic agent) and miRNA let-7d (as a tumor suppressor) using two...